Author

Siewert Hugelier

University of PennsylvaniaORCID 0000-0002-6224-652XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:microscopy & imaging analysis· 3 Assay:imaging· 2 Research Focus:spatial domain detection· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Melike LakadamyaliiD· 3 shared Charles BondiD· 2 shared A. Alejandro VilcaesiD· 1 shared Adriana N. Santiago-RuiziD· 1 shared Edward B. LeeiD· 1 shared Elena M. SorokinaiD· 1 shared Gabriela L. Correa· 1 shared Jiazheng XingiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

Melike LakadamyaliORCID

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3 papers

Recent·Most cited

Super-Resolution Imaging Uncovers Nanoscale Tau Aggregate Hyperphosphorylation Patterns in Human Alzheimers Disease Brain Tissue

Adriana N. Santiago-Ruiz, Siewert Hugelier, Gabriela L. Correa, Charles Bond, Edward B. Lee, Melike Lakadamyali

The paper uses super-resolution imaging to analyze nanoscale tau aggregates in AD and PART brain tissues, revealing hyperphosphorylation patterns and morphological differences.

Advanced Science · Nov 19, 2025Peer-reviewedBiophysics

Sparse delivery of Synaptobrevin-2 to neurons using extracellular vesicles

Victoria Hannett, A. Alejandro Vilcaes, Siewert Hugelier, Qing Tang, Melike Lakadamyali, Natalí L. Chanaday

This study tracks Syb2-containing extracellular vesicles in neurons to reveal their endocytic pathways and rapid incorporation into synaptic vesicles.

bioRxiv · Nov 4, 2025 · PreprintCell Biology

Multiplexed DNA-PAINT Imaging of the Heterogeneity of Late Endosome/Lysosome Protein Composition

Charles Bond, Siewert Hugelier, Jiazheng Xing, Elena M. Sorokina, Melike Lakadamyali

This study uses multiplexed DNA-PAINT imaging to reveal cell-type specific subpopulations of late endosomes/lysosomes with unique protein compositions.

The Journal of Cell Biology · Oct 9, 2024Peer-reviewedCell Biology