Melike Lakadamyali

This study identifies chromatin stability as critical for preserving chondrocyte function during expansion and shows that Fludarabine maintains phenotype by stabilizing chromatin and reducing STAT1 activity.

This study uses FLARE-ExM to examine changes in tendon cellular and extracellular structures under healthy and perturbed conditions, revealing structural alterations in response to mechanical stress.

This study uses μMap photo-proximity labeling to compare the interactomes of α-synuclein monomers and fibrils in mouse brain lysate to investigate synucleinopathy mechanisms.

This study identifies active transport of tRNAs via endolysosomal vesicles in large cells, showing that LeuRS facilitates this process and its disruption impairs protein synthesis and cell size.

The paper uses super-resolution imaging to analyze nanoscale tau aggregates in AD and PART brain tissues, revealing hyperphosphorylation patterns and morphological differences.

This study tracks Syb2-containing extracellular vesicles in neurons to reveal their endocytic pathways and rapid incorporation into synaptic vesicles.

The paper identifies SWING regions as chromatin domains that mediate gene regulation through interactions with nuclear speckles and the lamina, showing their role in development and disease.

The paper shows chromatin compaction in Drosophila neurons follows a power law with nuclear volume during interphase and mitosis, regulated by molecular cues and phase separation.

This study combines theoretical modeling and high-resolution imaging to reveal how chromatin-lamina interactions and environmental cues influence LAD formation and thickness in hMSCs.

O-SNAP extracts and classifies chromatin features from SMLM data, detecting subtle changes in chromatin organization across biological transitions.

The paper develops a polymer model integrating super-resolution imaging and epigenomic sequencing to show how epigenetic reactions shape 4D chromatin organization and influence gene expression and metastatic potential.

This study uses multiplexed DNA-PAINT imaging to reveal cell-type specific subpopulations of late endosomes/lysosomes with unique protein compositions.

The paper identifies a retrograde transit filter in distal axons mediated by optineurin that regulates mitochondrial homeostasis, independent of PINK1 and parkin.

The paper identifies reticular adhesions, a new class of adhesion complex that maintains cell-matrix attachment during mitosis, independent of classical adhesion components.