A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions
Damien Detraux, Marino Caruso, Louise Feller, Maude Fransolet, Sébastien Meurant, Julie Mathieu, Thierry Arnould, Patricia Renard
This study shows that heme synthesis and succinate regulate pluripotent state transitions in ESCs by affecting signaling pathways and triggering 2C-like reprogramming.
eLife · Jul 10, 2023Peer-reviewedDevelopmental Biology