Damien Detraux

This paper designs a synthetic ligand, H2F, that induces HER2-FGFR proximity to reprogram fibroblasts into myogenic cells and promote myogenic regeneration.

The paper designs TrkA agonists that activate neuronal differentiation and neurite outgrowth without triggering pain-related gene expression.

This study shows that heme synthesis and succinate regulate pluripotent state transitions in ESCs by affecting signaling pathways and triggering 2C-like reprogramming.