Author

Alan Costello

Scripps Research InstituteORCID 0000-0002-6266-5070Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Organism:plant (other)· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Ahmed H. BadraniD· 2 shared Alexander A. PetersoniD· 1 shared David L. LansteriD· 1 shared Gavriela D. CarveriD· 1 shared James S. FraseriD· 1 shared Tushar RaskariD· 1 shared Zhiyi LiiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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2 shared papersBioengineering

Ahmed H. BadranORCID

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2 papers

Recent·Most cited

BioengineeringNucleic Acids ResearchPeer-reviewedJul 17, 2026

Structural adaptations for enhanced translation kinetics in evolved ribosomes

Tushar Raskar, Alan Costello, Ahmed H. Badran, James S. Fraser

This study structurally characterizes evolved ribosomes with enhanced translation kinetics, revealing how RNA structural adaptations influence translation efficiency.

DOI 10.1093/nar/gkag703

E. coliplant (other)

𝕏 PostBluesky

Synthetic BiologyNature BiotechnologyPeer-reviewedSep 11, 2024

Efficient Genetic Code Expansion Without Host Genome Modifications

Alan Costello, Alexander A. Peterson, David L. Lanster…·Ahmed H. Badran

This paper develops a plasmid-based codon compression strategy to improve non-canonical amino acid incorporation in E. coli, enabling the creation of new-to-nature peptides with multiple ncAAs.

28 citationstop 5%

E. coliproteomics

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