Chad Harland

The paper identifies novel recessive loci affecting lactation traits in cattle using non-additive QTL mapping on 124,000 sequence-imputed cows, revealing differences in genetic architecture between milk yield and composition traits.

The study examines gene-edited cloned calves and finds no off-target events or increased de novo mutagenesis compared to unedited controls.

Cattle pedigrees indicate up to ~30% of de novo mutations in male gametes and ~50% in female gametes arise during early cleavage divisions, leaving parental mosaicism and sibling sharing.