Thomas Lopdell

An integrative approach to prioritize candidate causal genes for complex traits in cattle

The paper tests three methods to identify causal genes for milk lipid traits in cattle using GWAS, transcriptomics, and gene ontology analysis, finding significant overlaps but limited power.

Non-additive QTL mapping of lactation traits in 124,000 sequence-imputed cattle reveals novel recessive loci

The paper identifies novel recessive loci affecting lactation traits in cattle using non-additive QTL mapping on 124,000 sequence-imputed cows, revealing differences in genetic architecture between milk yield and composition traits.

HandyCNV: Standardized Summary, Annotation, Comparison, and Visualization of CNV, CNVR and ROH

HandyCNV is an R package for summarizing, annotating, comparing, and visualizing CNV and ROH from SNP data, providing a standardized and user-friendly tool for human and livestock research.

A new mechanism for a familiar mutation - bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement

The paper re-examines the mechanism of the DGAT1 K232A mutation in bovine milk production, showing it modulates gene expression through splicing enhancement.

Multiple QTL underlie milk phenotypes at the CSF2RB locus

The paper identifies multiple QTL at the CSF2RB locus associated with milk yield and composition traits in dairy cattle and explores their genetic and molecular mechanisms.

Widespread cis-regulation of RNA-editing in a large mammal

The paper identifies cis-regulated RNA editing quantitative trait loci (edQTL) in cattle, linking them to gene expression and lactation traits.