Author
Livestock Improvement CorporationORCID 0000-0001-9044-047XUnclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Houcheng Li, Huicong Zhang, Di Zhu, Pengju Zhao, Zhenyu Wei, Jiaqi Lu, Mian Gong, Qi Zhang, Weijie Zheng, Xia Liu, Dailu Guan, Jinyan Teng, Qing Lin, Yongjie Tang, Yahui Gao, , Lingzhao Fang
The paper presents CattleGTEx, a resource characterizing regulatory effects in cattle, resolving GWAS signals and providing insights into adaptive evolution and selection.
bioRxiv · Mar 21, 2026 · PreprintGenetics
Seyed Mohammad Ghoreishifar, Iona M. MacLeod, Amanda Jane Chamberlain, Zhiqian Liu, Thomas Lopdell, Mathew D. Littlejohn, Ruidong Xiang, J.E. Pryce, Michael Edward Goddard
The paper tests three methods to identify causal genes for milk lipid traits in cattle using GWAS, transcriptomics, and gene ontology analysis, finding significant overlaps but limited power.
PLoS Genetics · May 30, 2025Peer-reviewedGenomics
Edwardo Reynolds, Thomas Lopdell, Yu Wang, Kathryn Tiplady, Chad Harland, Thomas Johnson, Catherine Neeley, Katie Carnie, Richard G. Sherlock, Christine Couldrey, Stephen R. Davis, B.L. Harris, Richard J. Spelman, Dorian J. Garrick, Mathew D. Littlejohn
The paper identifies novel recessive loci affecting lactation traits in cattle using non-additive QTL mapping on 124,000 sequence-imputed cows, revealing differences in genetic architecture between milk yield and composition traits.
Genetics Selection Evolution · Jan 24, 2022Peer-reviewedGenetics
Swati Jivanji, Chad Harland, Sally Cole, Brigid Brophy, Dorian J. Garrick, Russell G. Snell, Mathew D. Littlejohn, Götz Laible
The study examines gene-edited cloned calves and finds no off-target events or increased de novo mutagenesis compared to unedited controls.
BMC Genomics · Jun 17, 2021Peer-reviewedGenomics
Götz Laible, S-A. Cole, B. Brophy, J. Wei, Shane R. Leath, Swati Jivanji, Mathew D. Littlejohn, David N. Wells
This study edits the PMEL gene in Holstein Friesian cattle to lighten coat color, demonstrating its role in heat stress adaptation and validating genome editing for livestock improvement.
bioRxiv · Sep 15, 2020 · PreprintGenetics
Tania Fink, Thomas Lopdell, Kathryn Tiplady, Renée R. Handley, Thomas Johnson, Richard J. Spelman, Stephen R. Davis, Russell G. Snell, Mathew D. Littlejohn
The paper re-examines the mechanism of the DGAT1 K232A mutation in bovine milk production, showing it modulates gene expression through splicing enhancement.
BMC Genomics · Aug 26, 2020Peer-reviewedMolecular Biology
Thomas Lopdell, Kathryn Tiplady, Christine Couldrey, Thomas Johnson, Michael Keehan, Stephen R. Davis, B.L. Harris, Richard J. Spelman, Russell G. Snell, Mathew D. Littlejohn
The paper identifies multiple QTL at the CSF2RB locus associated with milk yield and composition traits in dairy cattle and explores their genetic and molecular mechanisms.
Genetics Selection Evolution · Jan 24, 2019Peer-reviewedGenomics
Thomas Lopdell, Victoria Hawkins, Christine Couldrey, Kathryn Tiplady, Stephen R. Davis, B.L. Harris, Russell G. Snell, Mathew D. Littlejohn
The paper identifies cis-regulated RNA editing quantitative trait loci (edQTL) in cattle, linking them to gene expression and lactation traits.
RNA · Dec 10, 2018Peer-reviewedGenomics