Satoru Osuka

This study identifies radiation-induced collagen I&III accumulation as a driver of immunosuppressive evolution in recurrent glioblastoma and shows that targeting this pathway improves immunotherapy outcomes.

This study identifies SON as a suppressor of circRNA biogenesis in glioblastoma, linking circRNA depletion to PKR signaling and radiation resistance.

This paper establishes a humanized mouse model of glioblastoma using patient-derived xenografts to study immune infiltration and tumor heterogeneity, finding immune cell profiles similar to recurrent human GBM.