BiochemistryNucleic Acids ResearchPeer-reviewed
Bottlebrush Polymer Conjugates for Enhanced Antisense Oligonucleotide Therapy in Myotonic Dystrophy Type 1
Yao Li, Christopher Oetheimer, Yuyan Wang…·Ke Zhang
This paper demonstrates that bottlebrush polymer conjugates enhance antisense oligonucleotide therapy for DM1, improving muscle distribution and splicing correction in a mouse model.
DOI 10.1093/nar/gkag619