Bottlebrush Polymer Conjugates for Enhanced Antisense Oligonucleotide Therapy in Myotonic Dystrophy Type 1
Yao Li, Christopher Oetheimer, Yuyan Wang, Gyu Seong Heo, Jiaqi Wu, Rong Seng Chang, Wei Zhang, Elle Schnieder, Junjie Chen, Yang Fang, Yun Wei, Keqing Nian, Hengli Zhang, Lauren Sherman, Yongjian Liu, Ke Zhang
This paper demonstrates that bottlebrush polymer conjugates enhance antisense oligonucleotide therapy for DM1, improving muscle distribution and splicing correction in a mouse model.
Nucleic Acids Research · Jun 22, 2026Peer-reviewedBiochemistry