Abhijit Dasgupta

Alzheimer's mouse model proteomes capture 30% (amyloid-only models) to 42% (adding tau and splicing models) of consensus human AD protein changes; in 5xFAD, plaques slow degradation of plaque-associated proteins.

This study uses computational methods to identify drugs targeting ACE2 and AT1R to mitigate cytokine storm in COVID-19, highlighting Lomefloxacin and Fostamatinib as promising candidates.

The paper shows that catestatin reduces ER stress and improves insulin sensitivity in obese mice, supported by in silico simulations.