Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome
Jay M. Yarbro, Xian Han, Abhijit Dasgupta, Ka Yang, Danting Liu, Him K. Shrestha, Masihuz Zaman, Zhen Wang, Kaiwen Yu, Dong Geun Lee, David Vanderwall, Mingming Niu, Huan Sun, Boer Xie, Ping‐Chung Chen, , Junmin Peng
Alzheimer's mouse model proteomes capture 30% (amyloid-only models) to 42% (adding tau and splicing models) of consensus human AD protein changes; in 5xFAD, plaques slow degradation of plaque-associated proteins.
Nature Communications · Feb 11, 2025Peer-reviewedBiochemistry✦ In-depth digest