Jay M. Yarbro

This study evaluates false discovery rate and statistical power in DIA proteomics using technical replicates and spike-in experiments, revealing discrepancies between nominal and true FDR and showing power dependence on fold change and abundance.

The paper presents a cell type-resolved proteomic atlas of Alzheimer's disease mouse models, identifying thousands of cell-specific protein changes and highlighting astrocyte-microglia signaling.

The paper quantifies the proteomic composition of amyloid plaques in AD models and human brains, revealing stage-dependent remodeling and conserved proteins across species.

This study shows that midkine reduces Aβ fibril formation and amyloid plaque development in Alzheimer's disease models.

Alzheimer's mouse model proteomes capture 30% (amyloid-only models) to 42% (adding tau and splicing models) of consensus human AD protein changes; in 5xFAD, plaques slow degradation of plaque-associated proteins.

The paper presents Turnover-PPT, a resource mapping protein and phosphoprotein turnover across mouse tissues and brain regions, revealing tissue-specific protein lifetimes and phosphorylation's impact on stability.