A Novel Therapeutic Approach: Gamma Secretase Inhibitor Enhances Radiotherapy and Checkpoint Blockade Therapy via Reprogramming of the Tumor Microenvironment
Q. Wang, Debarshi Banerjee, Erin C. Connolly, Claire Vanpouille‐Box, Carrie J. Shawber, Rami Sesha Vanguri, Michael Kissner, M. L. Miller, Darrell J. Yamashiro, Eileen P. Connolly
This study shows that combining gamma secretase inhibitor with radiotherapy and checkpoint blockade therapy reprograms the tumor microenvironment to enhance antitumor immunity.
bioRxiv · Jun 1, 2026 · PreprintCancer Biology