Venkata Shiva Mandala

This study uses fluorescence microscopy and compositional analysis to show that plasma membrane proteins and lipids segregate into protein-rich domains and protein-poor regions, suggesting functional segregation of membrane processes.

The paper uses cryo-EM to show that hyperpolarization-induced displacement of the S4 helix in Kv2.1 channels causes pore constriction by altering interactions with S6 helices, similar to EAG1 channels.