This study shows TSPO deficiency increases white adipose tissue mass and lipid accumulation by disrupting the TSPO-PPIX axis, affecting lipid metabolism and mobilization.

bioRxiv · Sep 14, 2025 · PreprintPathology

Analytical validation and clinical utilization of K-4CARETM: a comprehensive genomic profiling assay with personalized MRD detection

Thien-Phuc Nguyen-Hoang, Tien Anh Nguyen, Nam H. B. Tran, Van‐Anh Nguyen Hoang, Hong Thuy Thi Dao, Vu-Uyen Tran, Yến Nhi Nguyễn, Anh Tuấn Nguyễn, Cam Tu Nguyen Thi, Thanh Thuy Thi, Duy Sinh Nguyen, Hoai‐Nghia Nguyen, Hoa Giang, Lan N. Tu

This paper validates a comprehensive genomic profiling assay, K-4CARE, for detecting genetic variants and ctDNA, showing high sensitivity and specificity across multiple cancer types.

Frontiers in Molecular Biosciences · Feb 9, 2024Peer-reviewedGenetic & Genomic Medicine

microRNA Expression Levels Change in Neonatal Patients During and After Exposure to Cardiopulmonary Bypass

Lance Y. Hsieh, Lan N. Tu, Alison G. Paquette, Nataliya Kibiryeva, Jennifer Marshall, Douglas C. Bittel, James E. O’Brien, Kasey C. Vickers, Peter Pastuszko, Vishal Nigam

The paper identifies miRNA expression changes in neonatal patients during and after cardiopulmonary bypass, linking them to inflammation and signal transduction pathways.

Journal of the American Heart Association · Aug 24, 2022Peer-reviewedDevelopmental Biology