Vimal Selvaraj

From blood to pluripotency: Fibrocytes as a reprogrammable somatic cell source for bovine iPSCs

This study identifies fibrocytes as a reprogrammable somatic cell source for bovine iPSCs, showing their molecular identity and successful reprogramming into pluripotent stem cells.

Flexible oocyte manipulation with delayed maturation and improved SCNT efficiency using induced pluripotent stem cells

This study improves SCNT efficiency in cattle by delaying oocyte maturation and using biPSCs as donor nuclei, resulting in higher fusion and blastocyst rates.

STAR/STARD1: a mitochondrial intermembrane space cholesterol shuttle degraded through mitophagy

The paper identifies STAR/STARD1 as a mitochondrial cholesterol shuttle degraded by mitophagy, explaining its role in steroid metabolism and lipid disorders.

Target validation uncouples TSPO from 19-Atriol-mediated inhibition of steroidogenesis and reveals true enzymatic targets

This study shows 19-Atriol inhibits steroidogenesis by directly targeting 3β-HSD and other enzymes, not via TSPO, resolving a long-standing mechanistic confusion.

TSPO deficiency reveals a novel role for porphyrins in regulating white adipose tissue lipid metabolism

This study shows TSPO deficiency increases white adipose tissue mass and lipid accumulation by disrupting the TSPO-PPIX axis, affecting lipid metabolism and mobilization.