Meng Xie

This study shows that palmitoylation of p75NTR reduces its stability and APP trafficking to lysosomes, increasing Aβ accumulation and neuropathology in AD.

This study shows that p75NTR signaling through the RhoA/ROCK pathway contributes to Alzheimer's Disease tauopathy, with specific receptor variants reducing neurodegeneration and cognitive impairment.

This study shows that p75NTR internalization differs between hippocampal and cerebellar neurons, regulated by distinct signaling pathways involving RhoA and NF-kB.

This study shows that impairing p75NTR function in adult forebrain excitatory neurons reduces AD pathology and cognitive deficits, even when applied during advanced disease stages.

This study compares immune system and microbiome differences in C57BL/6 mice exposed to different housing and microbial conditions, showing how environment affects immune traits.

This study shows that astrocyte p75NTR regulates cholesterol metabolism, reducing Aβ burden and cognitive impairment in Alzheimer's Disease.

The paper identifies a unique subpopulation of adipocytes in mouse perirenal adipose tissue that originates from brown-to-white conversion and reverts to a thermogenic state under cold exposure.