Author

Sridhar Nimmagadda

Johns Hopkins UniversityORCID 0000-0002-6413-7191Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Assay:imaging· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Ajay SharmaiD· 2 shared Kuldeep GuptaiD· 2 shared Akhilesh Mishra· 1 shared Akhilesh MishraiD· 1 shared Burles Avner JohnsoniD· 1 shared David James McConkeyiD· 1 shared Dhanush S. BankaiD· 1 shared Hoffman-Censits JeaniD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Ajay SharmaORCID

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3 papers

Recent·Most cited

SuFEx and macrocyclic chelation define orthogonal reactivity domains enabling isotopically versatile radiopharmaceuticals from a single peptide precursor

A Sharma, Akhilesh Mishra, Kuldeep Gupta, Sridhar Nimmagadda

This paper introduces a method using SuFEx chemistry and macrocyclic chelation to enable isotopically versatile radiopharmaceuticals from a single peptide precursor.

bioRxiv · Jun 23, 2026 · PreprintCancer Biology

Nectin-4 PET For Optimizing Enfortumab Vedotin Dose-Response In Urothelial Carcinoma

Akhilesh Mishra, Ajay Sharma, Kuldeep Gupta, Dhanush S. Banka, Burles Avner Johnson, Hoffman-Censits Jean, Peng Huang, David James McConkey, Sridhar Nimmagadda

This paper uses Nectin-4 PET imaging to assess target engagement and optimize dosing of enfortumab vedotin in urothelial carcinoma, finding that PET metrics better predict therapeutic response than dose or baseline expression.

Science Advances · Jan 7, 2026Peer-reviewedCancer Biology

SNP2SIM: A modular workflow for standardizing molecular simulation and functional analysis of protein variants

Matthew McCoy, Vikram S. Shivakumar, Sridhar Nimmagadda, Mohsin Saleet Jafri, Subha Madhavan

SNP2SIM provides a modular workflow for generating molecular simulations of protein variants to support functional analysis and drug development.

BMC Bioinformatics · Apr 3, 2019Peer-reviewedBioinformatics