This study identifies the decameric repeat (DR) of PSGL-1 as an essential antiviral unit that restricts HIV-1 infectivity by hindering virion attachment to target cells.

bioRxiv · May 14, 2025 · PreprintImmunology

PSGL-1 excludes HIV Env from virion surface through spatial hindrance involving structural folding of the decameric repeats (DR)

Sameer Tiwari, Bryan M. Delfing, Han Yang, Christopher Lockhart, Amrita Haikerwal, Abdul A. Waheed, Eric O. Freed, Mohsin Saleet Jafri, Dmitri K. Klimov, Yuntao Wu

This study identifies PSGL-1's decameric repeats as critical for excluding HIV Env from virions through structural folding that spatially hinders Env incorporation.

bioRxiv · Dec 28, 2024 · PreprintMicrobiology

lncRNAKB: A comprehensive knowledgebase of long non-coding RNAs

Fayaz Seifuddin, Komudi Singh, Abhilash Suresh, Jennifer Judy, Yun-Ching Chen, Vijender Chaitankar, Ilker Tunc, Xiangbo Ruan, Ping Li, Yi Chen, Haiming Cao, Richard S. Lee, Fernando S. Goes, Peter P. Zandi, Mohsin Saleet Jafri, Mehdi Pirooznia

The paper introduces lncRNAKB, a comprehensive knowledgebase of 77,199 human lncRNAs with expression, conservation, and cis-eQTL data from GTEx.

Scientific Data · Oct 5, 2020Peer-reviewedBioinformatics

SNP2SIM: A modular workflow for standardizing molecular simulation and functional analysis of protein variants

Matthew McCoy, Vikram S. Shivakumar, Sridhar Nimmagadda, Mohsin Saleet Jafri, Subha Madhavan

SNP2SIM provides a modular workflow for generating molecular simulations of protein variants to support functional analysis and drug development.

BMC Bioinformatics · Apr 3, 2019Peer-reviewedBioinformatics