Elevated SUN1 promotes aging-related polarity defects through mechanical coupling microtubules to the nuclear lamina
Yutao Li, Mengqi Chen, Susumu Antoku, Junjun Ding, Kaiyao Huang, Gregg G. Gundersen, Wakam Chang
This study shows elevated SUN1 disrupts cell polarity by coupling microtubules to the nuclear lamina, affecting mechanical force transmission during aging.
bioRxiv · Jan 15, 2025 · PreprintCell Biology