Actin Networking Collapse Under STAT5A Deficiency Drives Mitochondrial Dysfunction and Autocrine IFN-beta Production
Boyue Sun, Mathumathi Krishnamohan, Reinat Nevo, Eyal Zoler, Benjamin Geiger, Gideon Schreiber
This paper shows that STAT5A deficiency disrupts actin networks, leading to mitochondrial dysfunction and IFN-beta production, which can be reversed by restoring ACTN1.
bioRxiv · May 26, 2025 · PreprintCell Biology