Benjamin Geiger

This study identifies that a synthetic immune niche enhances T cell cytotoxicity by accelerating lytic hit delivery, not by increasing target encounters or conjugate stability.

This paper shows that a synthetic immune niche with CCL21 and ICAM1 boosts CAR T-cell expansion and potency, increasing cell yield and CAR T-cell frequency.

This study shows that VASP and zyxin are required for the assembly of aligned actin bundles with uniform polarity at focal adhesions, while tropomyosin-decorated actin layers remain unaffected.

This study identifies markers distinguishing TIL expansion properties and develops SIN-based strategies to enhance expansion and activation of both low- and high-expanding TILs.

This study identifies elevated surface La as a cause of hyperfusion and impaired resorption in osteopetrosis and shows that inhibiting La can restore osteoclast function.

This paper shows that STAT5A deficiency disrupts actin networks, leading to mitochondrial dysfunction and IFN-beta production, which can be reversed by restoring ACTN1.

This study investigates the molecular interactions between SNX10, CLC-7, and OSTM1 in osteoclasts, showing they regulate lysosome distribution and fusion during osteoclastogenesis.

This study investigates how a synthetic immune niche modulates T-cell proliferation and cytotoxicity, finding that these properties are negatively correlated and differentially regulated by activation mode.

This study shows that ERBB2 activates YAP signaling through phosphorylation, driving EMT-like processes and cardiac regeneration in mice after injury.