Author

Catherine Freitag Clarke

University of California, Los AngelesORCID 0000-0002-6426-3833Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1 Organism:yeast· 1

Frequent Co-Authors

Lucía Fernández-del-RíoiD· 2 shared Anish NagiD· 1 shared David Schapiro· 1 shared Eduardo BoidoiD· 1 shared Eduardo Manta· 1 shared Eduardo S. DellacassaiD· 1 shared Eugen WidmeieriD· 1 shared Florian BuergeriD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Lucía Fernández-del-RíoORCID

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2 papers

Recent·Most cited

Tracing the Path from 4-Hydroxyphenylpyruvate to the Benzoquinone Ring of Q6 and the p-aminobenzoate pathway in Yeast

María José Valera, Mauricio Mastrogiovanni, Lucía Fernández-del-Río, Eduardo Boido, Juan Carlos Ramos, Eduardo Manta, Eduardo S. Dellacassa, Rafael Radí, Catherine Freitag Clarke, Francisco Carrau

The paper identifies the 4-hydroxyphenylpyruvate pathway in yeast for synthesizing the benzoquinone ring of coenzyme Q6 and shows metabolic flexibility through the p-aminobenzoate pathway.

bioRxiv · Jun 25, 2026 · PreprintBiochemistry

ADCK4 deficiency destabilizes the coenzyme Q complex, which is rescued by 2,4-dihydroxybenzoic acid treatment

Eugen Widmeier, Seyoung Yu, Anish Nag, Youn Wook Chung, Makiko Nakayama, Lucía Fernández-del-Río, Hannah Hugo, David Schapiro, Florian Buerger, Won‐Il Choi, Martin Helmstädter, Jae Woo Kim, Ji-Hwan Ryu, Min Goo Lee, Catherine Freitag Clarke, , Heon Yung Gee

This study shows ADCK4 deficiency causes CoQ10 deficiency and mitochondrial dysfunction in podocytes, which is rescued by 2,4-dihydroxybenzoic acid treatment.

Journal of the American Society of Nephrology · May 7, 2020Peer-reviewedGenetics