Christie Mitchell Ballantyne

This study identifies a liver-to-atria inflammatory axis driven by osteopontin in MASH, leading to atrial remodeling and arrhythmia, with potential therapeutic targets.

This paper develops a machine learning framework to impute cross-platform proteomic data, improving replication of epidemiological findings and protein quality scoring.

The paper identifies plasma proteins associated with clonal hematopoiesis and links them to cardiovascular disease through proteomic and genetic analyses.

cpiVAE improves cross-platform proteomics imputation between Olink and SomaScan, achieving higher correlation than KNN and WNN, and enabling better phenotype associations.

The paper introduces a CN caller for KIV-2 repeats using short reads, showing high accuracy and demonstrating its correlation with Lp(a) levels and population-specific CN distributions.

The paper identifies ancestry-specific and shared genetic regulators of plasma proteins in European and African populations, revealing novel causal relationships and shared pQTLs.

This study identifies 17 genetic loci associated with sleep duration and lipid levels, offering potential druggable targets for dyslipidemia in individuals with sleep disturbances.

This study evaluates an AI assistant using GPT-4 and RAG to interpret pharmacogenomic results, showing improved performance over ChatGPT 3.5 in specialized queries.

This study analyzes 4,187 participants over 21 years to identify factors influencing the development of clonal hematopoiesis, finding age, sex, and dyslipidemia as significant predictors.

The paper uses bidirectional Mendelian randomization to show LTL lengthening increases CHIP risk, while CHIP accelerates LTL shortening, with modest mediation between CHIP and CAD via LTL.

This study identifies 35 genes associated with circulating lipid levels using rare coding variants from 170,000 exomes across multiple ancestries.

This study shows that clonal hematopoiesis, especially with DDR gene mutations, increases the risk of peripheral artery disease and atherosclerosis.

This study develops a polygenic risk score for eGFR and shows its association with kidney disease outcomes and plasma proteins in the ARIC study.

The paper analyzes de novo mutations in 1,465 genomes to show similar mutation rates across ancestries but reduced rates in the Amish population, with environmental factors possibly influencing mutation rates.

The paper identifies 49 novel blood lipid loci associated with gene-sleep interactions in 126,926 individuals across 5 ancestry groups, with gene-short-sleep interactions explaining 4.25% of triglyceride variance.