Author

Luca Simula

Centre National de la Recherche ScientifiqueORCID 0000-0002-6440-1810Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Anaïs Vermare· 2 shared Emmanuel DonnadieuiD· 2 shared Frédéric PendinoiD· 2 shared Nadège BercoviciiD· 2 shared Adrien RouaultiD· 1 shared Alexandre BoissonnasiD· 1 shared Andrea ValentiniiD· 1 shared Annavera VenturaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersImmunology

Anaïs Vermare

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintMay 29, 2026

Monocytes promote intraepithelial infiltration of effector memory CD8+ T cells in regressing tumors

Anaïs Vermare, Annavera Ventura, Adrien Rouault…·Nadège Bercovici

The paper identifies monocyte interactions with CD8+ T cells during tumor regression, showing their role in promoting T-cell infiltration and anti-tumor immunity.

DOI 10.64898/2026.05.28.728475

mousescRNA-seq

𝕏 PostBluesky

ImmunologyMolecular TherapyPeer-reviewedApr 4, 2026

An in vivo CRISPR screen unveils top target genes to improve CAR-T cell efficacy in a solid tumor model

Mattia Fumagalli, Dongjie An, Luca Simula…·Frédéric Pendino

This study uses an in vivo CRISPR screen to identify genes that enhance CAR-T cell efficacy in a solid tumor model, finding that disrupting REGNASE-1, SOCS1, PTPN2, and P16/NK4A improves tumor eradication.

4 citationstop 1%

humangenetic perturbation / CRISPR

𝕏 PostBluesky