Author

Thomas Steven Dexheimer

Frederick National Laboratory for Cancer ResearchORCID 0000-0002-6444-3121Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Beverly A. TeicheriD· 2 shared James H. DoroshowiD· 2 shared Melinda G. HollingsheadiD· 2 shared Naoko TakebeiD· 2 shared Nathan P. CoussensiD· 2 shared Thomas E. SilversiD· 2 shared Joel MorrisiD· 1 shared Li CheniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Beverly A. TeicherORCID

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2 papers

Recent·Most cited

Combinations of RAS pathway inhibitors with targeted agents are active in spheroids of patient-derived cells with oncogenic KRAS variants from multiple cancer types

Zahra Davoudi, Thomas Steven Dexheimer, Nathan P. Coussens, Thomas E. Silvers, Raymond G. Fox, Samantha B. Kemp, Poorva Juneja, Joel Morris, Melinda G. Hollingshead, Naoko Takebe, James H. Doroshow, Beverly A. Teicher

This study screens combinations of RAS pathway inhibitors with targeted agents in patient-derived spheroids with KRAS variants, identifying effective combinations that reduce viability.

Cancer Research Communications · Sep 17, 2025Peer-reviewedCancer Biology

Drug combinations with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids

Nathan P. Coussens, Thomas Steven Dexheimer, Thomas E. Silvers, Phillip R. Sanchez, Li Chen, Melinda G. Hollingshead, Naoko Takebe, James H. Doroshow, Beverly A. Teicher

The paper evaluates combinations of apoptosis pathway inhibitors with other agents in multi-cell type tumor spheroids to identify effective therapeutic strategies.

SLAS DISCOVERY · Apr 9, 2025Peer-reviewedCancer Biology