James H. Doroshow

This study screens combinations of RAS pathway inhibitors with targeted agents in patient-derived spheroids with KRAS variants, identifying effective combinations that reduce viability.

The paper evaluates combinations of apoptosis pathway inhibitors with other agents in multi-cell type tumor spheroids to identify effective therapeutic strategies.

This paper addresses data imbalance in drug response prediction by introducing a multi-objective optimization approach using a custom loss function to improve model performance.

This study identifies LZK as a therapeutic target in HNSCC by showing its regulation of c-MYC and GOF p53, and demonstrates PROTAC-mediated degradation as a potential treatment.

The paper presents a pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis of tumor regions and xenograft-transplant lymphoproliferative disorder prediction.