Nathan P. Coussens

Ampyrone (4-Aminoantipyrine) is a Direct Agonist of Human Tyrosinase and Potential Therapeutic for Oculocutaneous Albinism and Disorders of Hypopigmentation.

The paper identifies ampyrone as a direct activator of human tyrosinase, showing increased catalytic activity and melanin synthesis in melanocytes and skin cultures, suggesting potential therapeutic use for hypopigmentation disorders.

Combinations of RAS pathway inhibitors with targeted agents are active in spheroids of patient-derived cells with oncogenic KRAS variants from multiple cancer types

This study screens combinations of RAS pathway inhibitors with targeted agents in patient-derived spheroids with KRAS variants, identifying effective combinations that reduce viability.

Drug combinations with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids

The paper evaluates combinations of apoptosis pathway inhibitors with other agents in multi-cell type tumor spheroids to identify effective therapeutic strategies.

Small Molecule Inhibitors of the Human Histone Lysine Methyltransferase NSD2 / WHSC1 / MMSET Identified from a Quantitative High-Throughput Screen with Nucleosome Substrate

This study identifies five small molecule inhibitors of NSD2 through high-throughput screening and validates their activity in cell-based assays.