Author

Melinda G. Hollingshead

National Institutes of HealthORCID 0000-0002-1207-1397Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

James H. DoroshowiD· 3 shared Beverly A. TeicheriD· 2 shared Naoko TakebeiD· 2 shared Nathan P. CoussensiD· 2 shared Thomas E. SilversiD· 2 shared Thomas Steven DexheimeriD· 2 shared Alana L. WelmiD· 1 shared Ali Foroughi pouriD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

James H. DoroshowORCID

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3 papers

Recent·Most cited

Cancer BiologyCancer Research CommunicationsPeer-reviewedSep 17, 2025

Combinations of RAS pathway inhibitors with targeted agents are active in spheroids of patient-derived cells with oncogenic KRAS variants from multiple cancer types

Zahra Davoudi, Thomas Steven Dexheimer, Nathan P. Coussens…·Beverly A. Teicher

This study screens combinations of RAS pathway inhibitors with targeted agents in patient-derived spheroids with KRAS variants, identifying effective combinations that reduce viability.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologySLAS DISCOVERYPeer-reviewedApr 9, 2025

Drug combinations with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids

Nathan P. Coussens, Thomas Steven Dexheimer, Thomas E. Silvers…·Beverly A. Teicher

The paper evaluates combinations of apoptosis pathway inhibitors with other agents in multi-cell type tumor spheroids to identify effective therapeutic strategies.

6 citations

humanexperimental assay

𝕏 PostBluesky

BioinformaticsbioRxivPreprintOct 26, 2022

A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis

Brian S. White, X. Woo, Soner Koc…·Jeffrey H. Chuang

The paper presents a pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis of tumor regions and xenograft-transplant lymphoproliferative disorder prediction.

DOI 10.1101/2022.10.26.512745

mousehuman

𝕏 PostBluesky