Risk of mitochondrial deletions is affected by the global secondary structure of the human mitochondrial genome
Victor Shamanskiy, Alina A. Mikhailova, Evgenii O. Tretiakov, Kristina Ushakova, Alina G. Mikhailova, Sergey Oreshkov, Дмитрий Алексеевич Кнорре, Natalia Ree, Jonathan B. Overdevest, Samuel W. Lukowski, Irina S. Gostimskaya, Valerian A. Yurov, Chia‐Wei Liou, Tsu‐Kung Lin, Wolfram S. Kunz, , Konstantin Yu. Popadin
The paper identifies a contact zone in the human mitochondrial genome where deletions are more likely, linking it to aging and lifespan.
BMC Biology · May 8, 2023Peer-reviewedGenetics