Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic alpha-synuclein
Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Longgang Jia, Xiyu Ke, , Ted M. Dawson
The paper identifies Aplp1 and its complex with Lag3 as facilitators of pathologic alpha-synuclein transmission and toxicity, showing that disrupting this complex prevents neurodegeneration.
bioRxiv · May 1, 2021 · PreprintNeuroscience