Differentiation protocol and maturation shape the axial identity and synaptic state in human iPSC-derived spinal motor neurons
Alba Sansa, Vladimir Zhemkov, Monica Feole, Jaquelyn M. Villalba, Shaughn Bell, Clive Niels Svendsen
This study compares two protocols for generating human iPSC-derived spinal motor neurons, finding that the extended protocol produces more mature, spinal-specific neurons with enhanced synaptic features.
bioRxiv · Sep 17, 2026 · PreprintNeuroscience