Monica Feole

This study compares two protocols for generating human iPSC-derived spinal motor neurons, finding that the extended protocol produces more mature, spinal-specific neurons with enhanced synaptic features.

The paper investigates TDP-43's anterograde axonal transport in human neurons, revealing its interaction with multiple kinesin motors and implications for ALS pathology.

This study investigates the effects of the SORL1 p.Y1816C variant on neuronal function using iPSC-derived models, showing impaired SORLA maturation, altered APP processing, and disrupted axonal transport and electrophysiology.

This study shows that the Swedish FAD mutation disrupts axonal transport by increasing dynactin recruitment to APP motor assemblies, leading to retrograde movement and accumulation of APP in the soma.

This study investigates axonal swellings (AS) formation after traumatic brain injury, showing that AS occur independently of Ca2+ changes and involve cytoskeletal rearrangements that preserve axonal function.