Clive Niels Svendsen

This study compares two protocols for generating human iPSC-derived spinal motor neurons, finding that the extended protocol produces more mature, spinal-specific neurons with enhanced synaptic features.

The paper investigates TDP-43's anterograde axonal transport in human neurons, revealing its interaction with multiple kinesin motors and implications for ALS pathology.

The paper reports single-cell proteomic maps of human iPSCs and their differentiation into motor neurons, revealing proteomic and transcriptomic discordance.

This study develops iPSC-derived prostate organoids with and without BRCA2 mutations, showing tumorigenic changes and cancer markers in mutated organoids.

This study examines transcriptomic changes in grafted human neural progenitor cells and host retinal cells in a retinitis pigmentosa model, identifying mechanisms for vision preservation.

The paper analyzes ATAC-seq data from iPSC-derived motor neurons of ALS patients and controls to identify disease-specific chromatin accessibility changes and their predictive power for disease progression.

This paper demonstrates that proSAAS overexpression protects dopaminergic neurons and reduces transsynaptic α-synuclein spread in Parkinson's disease models.

This study shows that juvenile AAV9-MCT8 gene therapy improves neurological and behavioral deficits in an AHDS mouse model by restoring TH levels and gene expression.

The paper uses single-cell RNA-seq to identify early ALS signatures in iPSC-derived motor neurons across multiple models and platforms.

The paper performs an integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients to identify dysregulated pathways and validate them in vivo and in postmortem data.

The paper identifies POM121 as a critical nucleoporin affected by C9orf72 repeat RNA, leading to nuclear pore complex disassembly and neuronal toxicity in ALS/FTD.

This study compares 3-DGE and conventional mRNAseq, finding similar gene expression results with 3-DGE offering cost savings and scalability.

The paper develops a freezing protocol for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells, showing that slow-cooled cryopreserved samples yield comparable results to fresh cells.