Narayanaswamy Srinivasan

Structural network comparison of domains across remote homologues arising from different domain architectures

The paper compares structural networks of remote homologous protein domains from different architectures to assess how domain combinations influence structural and evolutionary changes.

SIRT2 attenuates stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling

This study identifies SIRT2 as a regulator of stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling, showing protective effects in mice.

Understanding the roles of secondary shell hotspots in protein-protein complexes

This study identifies secondary shell hotspots in protein-protein complexes, showing they are evolutionarily conserved and crucial for stability and activity.

Computational analysis of the effect of a binding protein (RbpA) on the dynamics of Mycobacterium tuberculosis RNA polymerase assembly

This study uses computational methods to analyze how RbpA affects RNA polymerase assembly dynamics in Mycobacterium tuberculosis, identifying structural changes and potential ligands for drug development.

Interfacial residues in protein-protein complexes are in the eyes of the beholder

The paper evaluates two methods for identifying interface residues in protein-protein complexes and shows they identify different residues with distinct properties and roles.

D614G substitution enhances the stability of trimeric SARS-CoV-2 spike protein

The paper analyzes the structural and energetic effects of the D614G substitution in SARS-CoV-2 spike protein, finding it enhances thermodynamic stability and may increase infectivity.

PB-kPRED: Knowledge-Based Prediction Of Protein Backbone Conformation Using A Structural Alphabet

The paper introduces kPred, a knowledge-based method for predicting protein backbone conformations using structural prototypes, achieving mean Q16 accuracies between 40.8% and 66.3%.