Giovanni Rosales‐Soto

This study shows chronic CaMKII activation drives skeletal muscle aging and sarcopenia, and partial inhibition in aged muscle improves function and shifts the transcriptome toward a youthful state.

This paper describes a scalable method to differentiate human pluripotent stem cells into hypothalamic arcuate neurons, which can model metabolic and reproductive disorders.

The paper uses a CaMKII activity reporter to study activation patterns in cardiac, skeletal muscle, and neurons, revealing differences in activation rates and subcellular localization.