An‐Chi Wei

The paper uses a CaMKII activity reporter to study activation patterns in cardiac, skeletal muscle, and neurons, revealing differences in activation rates and subcellular localization.

The paper models mitochondrial dynamics in pancreatic beta cells to show that fission occurs under metabolic stress when proton leak exceeds ATP synthesis.

The paper develops a mathematical model of mitochondrial retrograde signaling in yeast, revealing bistability and noise sensitivity in signal dynamics.

This paper shows that excessive O-GlcNAcylation causes heart failure and sudden death in mice, while reducing it protects against cardiac stress.

This study shows that myocardial BDNF signaling via YY1 regulates cardiac bioenergetics and mitochondrial function during stress.

This study shows mitochondrial CaMKII activation leads to metabolic reprogramming, energetic insufficiency, and dilated cardiomyopathy, with potential therapeutic targets identified.