Author

Gregory Zilberg

Icahn School of Medicine at Mount SinaiORCID 0000-0002-6575-508XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Assay:multiome· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Alexandra Kalia ParpounasiD· 2 shared Audrey L. WarreniD· 2 shared Daniel WackeriD· 2 shared Davide ProvasiiD· 2 shared Marta FilizolaiD· 2 shared Aileen M. VelaiD· 1 shared Alejandro AbrahamiD· 1 shared Bianca FiorilloiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPharmacology & Toxicology

Alexandra Kalia ParpounasORCID

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2 papers

Recent·Most cited

Structural and dynamic studies uncover a distinct allosteric modulatory site at the mu-opioid receptor

Haonan Zhang, Kirill A. Konovalov, Alexandra Kalia Parpounas, Davide Provasi, Shifan Yang, Alejandro Abraham, Aileen M. Vela, Audrey L. Warren, Gregory Zilberg, S. Wang, Marta Filizola, Daniel Wacker

This study identifies a novel allosteric site on the mu-opioid receptor using cryo-EM and MD simulations, revealing a lipid-sensitive mechanism for positive allosteric modulation.

Nature Communications · May 4, 2026Peer-reviewedPharmacology & Toxicology

Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR

Gregory Zilberg, Alexandra Kalia Parpounas, Audrey L. Warren, Bianca Fiorillo, Davide Provasi, Marta Filizola, Daniel Wacker

The paper investigates the agonist activity of tetracyclic antidepressants at 5-HT1eR and 5-HT1FR, revealing unique binding poses and receptor-specific mechanisms.

Science Advances · Apr 17, 2024Peer-reviewedNeuroscience