Pharmacology & ToxicologyNature CommunicationsPeer-reviewed
Structural and dynamic studies uncover a distinct allosteric modulatory site at the mu-opioid receptor
Haonan Zhang, Kirill A. Konovalov, Alexandra Kalia Parpounas…·Daniel Wacker
This study identifies a novel allosteric site on the mu-opioid receptor using cryo-EM and MD simulations, revealing a lipid-sensitive mechanism for positive allosteric modulation.