Author

Alexandra Kalia Parpounas

Icahn School of Medicine at Mount SinaiORCID 0009-0002-5837-4518Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Assay:multiome· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Audrey L. WarreniD· 2 shared Daniel WackeriD· 2 shared Davide ProvasiiD· 2 shared Gregory ZilbergiD· 2 shared Marta FilizolaiD· 2 shared Aileen M. VelaiD· 1 shared Alejandro AbrahamiD· 1 shared Bianca FiorilloiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPharmacology & Toxicology

Audrey L. WarrenORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyNature CommunicationsPeer-reviewedMay 4, 2026

Structural and dynamic studies uncover a distinct allosteric modulatory site at the mu-opioid receptor

Haonan Zhang, Kirill A. Konovalov, Alexandra Kalia Parpounas…·Daniel Wacker

This study identifies a novel allosteric site on the mu-opioid receptor using cryo-EM and MD simulations, revealing a lipid-sensitive mechanism for positive allosteric modulation.

1 citation

humancryo-EM

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NeuroscienceScience AdvancesPeer-reviewedApr 17, 2024

Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR

Gregory Zilberg, Alexandra Kalia Parpounas, Audrey L. Warren…·Daniel Wacker

The paper investigates the agonist activity of tetracyclic antidepressants at 5-HT1eR and 5-HT1FR, revealing unique binding poses and receptor-specific mechanisms.

7 citations

humanexperimental assay

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