Synergistic Antitumor Activity of SUMO1 degrader and Oxaliplatin through G6PD Inhibition in Colorectal Cancer
Sung Han Jung, Rakhim Roy, Yin Quan Zhao, Thomas M. O’Connell, Regan K. Wohlford, Dae-Ho Kim, Chunhai Hao, Anita C. Bellail
This study shows that combining SUMO1 degrader HB007 with oxaliplatin enhances antitumor effects in colorectal cancer by inhibiting G6PD and inducing ROS-mediated apoptosis.
bioRxiv · Apr 8, 2025 · PreprintCancer Biology