Author

Chunhai Hao

Indiana University School of MedicineORCID 0000-0002-6952-2232Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Anita C. Bellail· 2 shared Sung Han JungiD· 2 shared Anantha ShekhariD· 1 shared Bin Liu· 1 shared Cen Gao· 1 shared Dae-Ho KimiD· 1 shared Ho-Yin Lo· 1 shared Li‐Fan ZengiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Anita C. Bellail

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2 papers

Recent·Most cited

Synergistic Antitumor Activity of SUMO1 degrader and Oxaliplatin through G6PD Inhibition in Colorectal Cancer

Sung Han Jung, Rakhim Roy, Yin Quan Zhao, Thomas M. O’Connell, Regan K. Wohlford, Dae-Ho Kim, Chunhai Hao, Anita C. Bellail

This study shows that combining SUMO1 degrader HB007 with oxaliplatin enhances antitumor effects in colorectal cancer by inhibiting G6PD and inducing ROS-mediated apoptosis.

bioRxiv · Apr 8, 2025 · PreprintCancer Biology

Molecular glue degraders enhance CAPRIN1-dependent lysosomal degradation of APP in Alzheimer disease

Sung Han Jung, Raktim N. Roy, Xu Wang, Bin Liu, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Li‐Fan Zeng, Ho-Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Anantha Shekhar, Anita C. Bellail, Chunhai Hao

The paper identifies molecular glue degraders that selectively degrade APP via CAPRIN1-dependent lysosomal pathway in neurons, reducing Aβ production in AD mouse models.

bioRxiv · Dec 29, 2023 · PreprintNeuroscience