Alexandre A. Lussier

Intergenerational epigenetic signatures of prenatal adversity and their role in emerging child psychopathology

The paper examines how prenatal social disadvantage and psychosocial stress affect DNA methylation in children and their potential role in psychopathology.

Acute Ethanol Exposure Induces Stage-Specific Bioenergetic, Mitochondrial and Neurodevelopmental Transcriptional Remodeling in Human Forebrain Progenitors

This study shows that acute ethanol exposure causes stage-specific transcriptional changes in human forebrain progenitors, affecting mitochondrial and bioenergetic genes differently in early versus late progenitors.

Identification of Dynamic Genetic Influences on DNA Methylation from Birth to Adulthood

The paper identifies age-dependent methylation quantitative trait loci (longitudinal mQTLs) across the lifespan using blood DNAm data from two cohorts, finding consistent genotype-by-age effects and associations with multiple phenotypes.

Examining the epigenetic mechanisms of childhood adversity and sensitive periods: a gene set-based approach

The paper investigates how childhood adversity during sensitive periods affects DNA methylation in genes regulating developmental plasticity using a gene set-based approach.

Socioeconomic changes predict genome-wide DNA methylation in childhood

This study shows that changes in socioeconomic environment during childhood affect DNA methylation at age 7, with middle childhood being a sensitive period for socioeconomic adversity's impact.

Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies

The paper assesses how changes in data versions and analytic methods affect the reproducibility of epigenome-wide association study results using the ALSPAC cohort.

Associations between indicators of socioeconomic position and DNA methylation: A systematic review

This review examines the association between socioeconomic position (SEP) and DNA methylation across the life course, finding that early-life SEP and persistent low SEP strongly influence DNAm patterns.

Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression

The paper examines how genetic pathways regulating sensitive periods and socioeconomic disadvantage interact to influence depression risk using genome-wide data and developmental gene expression patterns.

A prospective study of time-dependent exposures to childhood adversity and DNA methylation in childhood and adolescence

This study examines how time-varying childhood adversity affects DNA methylation across development, finding persistent effects at age 15 and resolving differences by adolescence.

Genetic susceptibility for major depressive disorder associates with trajectories of depressive symptoms across childhood and adolescence

The paper examines how genetic risk scores for depression relate to different patterns of depressive symptoms from childhood to adolescence.