Kerry James Ressler

This study shows that fentanyl interacts with the HPA axis over different timescales, with adrenal remodeling encoding stress history to influence fentanyl-seeking behavior.

This study shows that different types of acute stressors affect future fear learning differently in mice, with shock and social defeat enhancing fear memory recall, while restraint stress does not.

This study fine-maps PTSD GWAS data with amygdala eQTLs and shows FOXP2 expression is linked to increased PTSD risk, with functional validation in mice and humans.

This study identifies the anterior insula as a key circuit affected by early life maltreatment, showing its role in male social avoidance in adulthood.

This study shows that acute ethanol exposure causes stage-specific transcriptional changes in human forebrain progenitors, affecting mitochondrial and bioenergetic genes differently in early versus late progenitors.

The paper examines how childhood maltreatment affects brain structure in 3,711 individuals with MDD and PTSD, finding age- and sex-specific brain morphometric differences.

IBMMA improves neuroimaging analysis by handling missing data and large datasets, revealing new brain region findings overlooked by traditional methods.

This study examines the relationship between sleep patterns and anhedonia in male mice exposed to early-life stress, finding significant correlations between sleep architecture and anhedonic phenotypes.

The paper examines thalamic volume differences in trauma-exposed individuals with PTSD, MDD, and controls, finding specific volume reductions and associations with symptom severity and childhood trauma.

The paper investigates why large-scale neuroimaging tasks yield weak brain-mental health associations, finding a signal evocation bottleneck in common fMRI tasks.

This study develops a clinically relevant murine model of electroconvulsive stimulation to investigate its effects on social behavior and gene expression after chronic social defeat stress.

This study identifies specific types and ages of childhood maltreatment associated with accelerated brain aging in adulthood.

This study shows that spermidine supplementation improves depression symptoms by enhancing autophagy and correcting polyamine imbalances in both humans and mice.

The paper uses unsupervised machine learning to analyze fMRI data from an emotional face matching task, identifying large-scale brain networks and their relation to cognition and mental health.

The paper identifies a specific subset of BLA neurons that regulate alcohol seeking through environmental cue-reward associations, showing their activity is necessary for conditioned responses and memory recall.

This study investigates how sleep disruption affects anxiety-related circuits in female mice by examining synaptic changes in BLA to CRF-CeL projections.

This study shows that SKA2-regulated hyperactive secretory autophagy contributes to neuroinflammation and neurodegeneration in Alzheimer's disease.

The paper uses single nuclei RNA-sequencing to identify striatal cell types in humans and rhesus macaques and finds molecular changes linked to opioid use disorder.

This study shows that sleep deprivation after fear conditioning reduces fear memories in mice, possibly through BDNF-mediated neuroadaptations in the amygdala.

The paper introduces DeepOF, an open-source tool for analyzing social behavior in mice, and finds it detects distinct stress-induced social behavioral patterns.

This study shows that early-life stress in male mice reduces response bias for highly rewarded stimuli in a translational reward task, suggesting potential parallels with human depression.

This study shows PACAP modulates anxiety circuits by altering synaptic efficacy in BLA-ovBNST-adBNST pathways, leading to inhibition of adBNST and increased anxiety.

The paper identifies conserved oligodendrocyte dysregulation in mouse adversity models and human MDD, linking it to behavioral deficits and frontal cortex dysfunction.

This paper classifies PTSD vs. controls using MRI data from multiple sites, finding better performance when distinguishing PTSD from trauma-unexposed controls than trauma-exposed controls, and showing DVAE improves generalizability.

This study finds smaller total and subregional cerebellar volumes in PTSD compared to controls using a large dataset and advanced parcellation methods.

This study identifies a novel population of MC4R-expressing neurons in the infralimbic prefrontal cortex of mice that regulate food intake and executive function.

The paper assesses how changes in data versions and analytic methods affect the reproducibility of epigenome-wide association study results using the ALSPAC cohort.

The paper investigates the conservation of rare schizophrenia risk variants across diverse populations and finds consistent burden in constrained genes.

This study identifies Ptgs2 as a stress-induced gene in specific prefrontal cortical neurons that mediates anxiety-like behaviors in mice.

The paper identifies CS6 clusters as extracellular matrix microenvironments that support coordinated multi-dendrite synaptic plasticity in response to sensory stimuli.