An avidity-driven mechanism of extracellular BMP regulation by Twisted gastrulation
Gareth Moore, Raluca Revici, Lauren Forbes Beadle, Catherine Sutcliffe, Holly L. Birchenough, Clair Baldock, Hilary L. Ashe
The paper identifies and validates binding epitopes in Twisted gastrulation (Tsg) that mediate interaction with Sog/Chordin, revealing an avidity-driven mechanism for BMP gradient formation.
Development · Jan 8, 2026Peer-reviewedDevelopmental Biology