Morgan G. I. Langille

This study examines how bedrest affects gut and oral microbiomes in older adults, finding that inactivity reduces gut diversity and increases Bacteroides, while exercise mitigates these changes, and oral microbiome diversity is more strongly linked to frailty.

The paper updates the PICRUSt2 reference database with more bacterial and archaeal genomes and functional annotations, improving functional predictions from amplicon sequencing data.

JarrVis is an R Shiny tool that visualizes taxa-function relationships from meta-omic data, demonstrating its utility with three case studies.

The paper develops and validates a method to detect novel lateral gene transfer events in human microbiomes, identifying over 100K putative LGT events across >2K metagenomes.

This study evaluates how tool, parameter, and database choices affect metagenomic taxonomic classification performance across different datasets and applications.

The paper introduces POMS, a phylogeny-aware framework for identifying enriched functions in microbiome data, showing improved accuracy over existing methods in simulated and real datasets.

In 38 two-group 16S rRNA datasets, 14 differential abundance tools disagreed sharply; ALDEx2 and ANCOM-II were conservative and consistent, while edgeR and LEfSe inflated false positives.

PICRUSt2 places 16S rRNA variants into a 20,000-gene reference tree, predicting gene families, pathways and phenotypes; gene-family predictions matched or beat four tools against shotgun metagenomes.