GenomicsProceedings of the National Academy of SciencesPeer-reviewed
Perturbation-Specific Transcriptional Mapping for unbiased target elucidation of antibiotics.
Keith P. Romano, Josephine Bagnall, Thulasi Warrier…·Deborah Tan Hung
This paper introduces PerSpecTM, a method to predict antibiotic mechanisms of action by comparing transcriptional responses of new molecules to known perturbations, demonstrating its effectiveness with three new anti-Pseudomonas aeruginosa compounds.
9 citations