Jonathan Livny

This study identifies PSMε as a key molecular component that drives CD8+ T cell activation by commensal bacteria, offering a mechanism for immunotherapy without live bacterial colonization.

This study identifies a nitrite-responsive regulatory RNA locus in Bacteroides thetaiotaomicron that enhances resilience to nitrosative stress during intestinal inflammation.

This study engineers obligate anaerobic bacteria to tolerate oxygen, improving their survival in the gut.

This study shows how ETBF reprograms host metabolism to create an oxidative niche that supports its growth in the inflamed gut.

This paper introduces PerSpecTM, a method to predict antibiotic mechanisms of action by comparing transcriptional responses of new molecules to known perturbations, demonstrating its effectiveness with three new anti-Pseudomonas aeruginosa compounds.

The paper identifies mutations in the BarA/SirA regulatory pathway in persistent Salmonella infections, showing they reduce virulence and inflammation.